O122 The use of directly injectable cancer therapies: a systematic review

Abstract Introduction DIT allows for targeted delivery to a cancer. This could deescalate treatments through reduced use of systemic chemotherapy, radiotherapy dosage, and avoidance major surgery. Palliative cancers can benefit similar means maintain quality life avoid permanent interventions (such as stomas). There is no mainstream DIT. Therefore, the aim this review was assess role in all cancers. Methods A systematic search performed Pubmed, Web Science, Embase Google databases. Two authors independently searched literature extracted data onto dedicated proforma. Human animal studies were included. Results 8,380 papers identified, 49 included; comprising 1,087 patients lung, H+N, brain, oesophagogastric colorectal Four neoadjuvant DIT, where one showed lung tumours down staged an operative state. The remainder advantage survival or response. intra-tumoural cisplatin (in three studies) promise malignant airway obstruction, good responses shown > 50% (single report). Cisplatin also favourable palliative H+N (ORR=66% minority (4/49) exhibited grade 3 toxicity higher. Conclusion safe administer demonstrated palliation obstruction advanced/recurrent Further are required verify these results. Additionally, more reports determine its treatment. DIT:Direct injection chemotherapy ORR:objective response rate H+N:head neck